repression of pain sensation by the transcriptional regulator dream
| PAG Title | repression of pain sensation by the transcriptional regulator dream |
| PAG ID | WAG001454 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The molecular events that lead to the perception of pain are a key research field in medicine and drug discovery. The opioid receptors modulate pain sigling in response to endogenous peptide ligands and opiate drugs such as morphine. The kappa opioid receptor plays a key role in the profound algesia of opiates and is activated by the endogenous peptide ligand dynorphin, encoded by the prodynorphin gene. Production of prodynorphin is transcriptiolly regulated by a downstream regulatory element (DRE) in the prodynorphin gene. A transcription factor called DREAM (DRE antagonistic modulator) binds to the DRE and represses prodynorphin transcription when bound. DREAM binds calcium with 4 EF-hand motifs and the binding of DREAM to D is repressed in the presence of calcium. Many transcription factors are regulated by calcium indirectly through calcium sensitive kises and phosphatases, but DREAM is unique to date in being a transcription factor that directly binds calcium and is regulated by calcium binding. DREAM may also regulate other genes such as c-fos. |
| Species | Homo sapiens |
| nCoCo Score | 1,664 |
| Base PAG ID | WAG001454 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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